Evolve Case Study Answers Hiv

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Triangulation of social science studies within the ANRS 12249 Tas P trial will provide comprehensive insights into the acceptability and feasibility of the Tas P intervention package at individual, community, patient and health system level, to complement the trial’s clinical and epidemiological outcomes.It will also increase understanding of the causal impacts of UTT on social and economic outcomes, which will be critical for the long-term sustainability and routine UTT implementation.We constructed a multi-disciplinary research programme implemented as part of the ANRS 12249 Treatment-as-Prevention (Tas P) trial in South Africa.

Triangulation of social science studies within the ANRS 12249 Tas P trial will provide comprehensive insights into the acceptability and feasibility of the Tas P intervention package at individual, community, patient and health system level, to complement the trial’s clinical and epidemiological outcomes.It will also increase understanding of the causal impacts of UTT on social and economic outcomes, which will be critical for the long-term sustainability and routine UTT implementation.We constructed a multi-disciplinary research programme implemented as part of the ANRS 12249 Treatment-as-Prevention (Tas P) trial in South Africa.

Clinicaltrials.gov: NCT01509508; South African Trial Register: DOH-27-0512-3974.

Four large-scale cluster randomized trials are ongoing in Eastern and Southern Africa to measure the efficacy of a Universal Test and Treat (UTT) approach in ‘real life’ [1]: ANRS 12249 Tas P (Treatment–as-Prevention) in South Africa [2,3]; HPTN 071 Pop ART in South Africa and Zambia [4,5]; SEARCH in Kenya and Uganda [6] and the Botswana Combination Prevention project [7].

All four trials rely on some form of longitudinal population-based HIV surveillance approach to evaluate changes in HIV prevalence and, most importantly, in HIV incidence over time.

Following Granich and colleagues’ model published in the Lancet in 2009 [8], UTT interventions are built around two main components: Reports modelling the effects of UTT [9,10] suggest that the significant prevention benefits (i.e.

In both trial arms, rounds of home-based HIV testing are repeated every six months.

All trial participants identified as HIV-infected are referred to a local Tas P trial clinic situated in the trial cluster in which they live.

In terms of linkage to care and ART initiation, a recent meta-analysis of sub-Saharan African data published between 20, showed that, for 100 patients with a positive HIV test, 72 had a CD4 count performed, 40 were eligible for ART and only 25 started [14].

The 2013 World Health Organisation (WHO) guidelines on ART eligibility recommend initiation of ART at a CD4 count threshold of 500 cells/mm).

A social science research programme is nested within the ANRS 12249 Treatment-as-Prevention (Tas P) cluster-randomised trial in rural South Africa.

The programme aims to inform understanding of the (i) social, economic and environmental factors affecting uptake of services at each step of the continuum of HIV prevention, treatment and care and (ii) the causal impacts of the Tas P intervention package on social and economic factors at the individual, household, community and health system level.

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